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Wales coach Warren Gatland was not surprised when centre George North told him he would retire from international rugby, but to lose a player with 13 years and 120 caps at the highest level adds to the size of the rebuild of his squad.
Glasgow centre Stafford McDowall will make his second appearance for Scotland when he starts Saturday's Guinness Six Nations match against Ireland in Dublin.
Italy have made three changes to their side to face Wales in their final Guinness Six Nations game in Cardiff on Saturday as Lorenzo Pani comes in to replace the injured Ange Capuozzo at fullback.
France coach Fabien Galthie has named an unchanged team for their final Guinness Six Nations fixture against England in Lyon on Saturday (live on RTÉ2 and RTÉ Player), which means a second run at out-half for Thomas Ramos.
Warren Gatland will explain his selection choices for Wales' crucial Six Nations showdown with Italy when he addresses the media later today.
When Ireland head coach Andy Farrell announced his side for the opening round of the 2024 Guinness Six Nations against France, the inclusion of Joe McCarthy was one of the major talking points.
Injured Ireland winger Mack Hansen has been using his time off to reconnect with his Irish roots.
Antoine Frisch will not be capped by France this weekend and so remains Ireland-qualified, until the summer at least.