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Sevens star JC Pretorius will make his Lions debut off the bench ahead of the Lions' Challenge Cup encounter against French outfit Stade Francais at Stade Jean Bouin Stadium in Paris.
Hugo Keenan will make his 50th appearance for Leinster when they face Gloucester at Kingsholm in Saturday's Heineken Champions Cup tie (kick-off 1pm).
Sharks director of rugby Neil Powell has rolled out the heavy artillery for their Champions Cup clash against Bordeaux-Begles in Durban on Saturday.
The Bulls have named a strong line-up for Saturday's European Champions Cup game against Exeter Chiefs at Loftus Versfeld.
Munster head coach Graham Rowntree has sprung a major surprise, with Conor Murray dropped from the matchday squad for Saturday's crucial Heineken Champions Cup Round 3 game against Northampton Saints (live on RTÉ2 and RTÉ Player).
With the United Rugby Championship (URC) and the Champions Cup taking place in very different conditions in the northern and southern hemisphere, travelling teams have to adapt each week.
The penultimate round of a short pool stage, and by Sunday evening we can expect to see several of the knockout places confirmed.
Time and again over the last few months, Munster's players and coaches have spoken about the changes they're making to the way they play.