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David Montgomery rushed for 121 yards and three touchdowns as the Detroit Lions moved into first place in the NFC North with a 34-20 victory over the host Green Bay Packers on Thursday night.
D'Andre Swift rushed for 130 yards to help the visiting Philadelphia Eagles cruise to a 25-11 victory over the Tampa Bay Buccaneers on Monday night.
The Miami Dolphins rattled up the highest points total in the NFL since 1966 as they overwhelmed the winless Denver Broncos 70-20.
Raheem Mostert grabbed a pair of rushing touchdowns as the Miami Dolphins held off AFC East rivals the New England Patriots 24-17 for a second win on the road to start the season.
D'Andre Swift starred for the Philadelphia Eagles to secure their second win in two games, beating the Minnesota Vikings 34-28 at Lincoln Financial Field.
Four-time NFL MVP Aaron Rodgers will miss the rest of the season after tearing his Achilles tendon in his first league game for the New York Jets.
Green Bay Packers punter Dan Whelan became the Irish-born player to feature in an NFL game since 1985 when he made a highly encouraging competitive debut in his side's 38-20 victory over the Chicago Bears at Soldier Field.
David Montgomery's eight-yard touchdown run with 7:06 left on Thursday night propelled the visiting Detroit Lions to a season-opening, 21-20 win over the Super Bowl champion Kansas City Chiefs in the NFL's season-opening game.