Ruud van Nistelrooy returns to Manchester United with his struggling Leicester this weekend, aiming to inflict more pain on his former club in the FA Cup as Marcus Rashford targets a fresh start with Aston Villa. Holders United kick off the fourth round at home against the Foxes on Friday, with other standout ties including Villa against Tottenham and Brighton v Chelsea. Birmingham, co-owned by former NFL superstar Tom Brady, will eye an upset against Newcastle, while a struggling Manchester City aim to avoid a monumental shock at third-tier Leyton Orient.