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Che Adams notched a brace to give Southampton a 3-0 victory over Preston, a third home win in seven days and a clear view of the Sky Bet Championship automatic promotion places.
Leicester missed the chance to go four points clear at the top of the Championship after a 1-0 loss at Millwall.
Ipswich went back level on points with second-placed Leeds in the Championship as they beat Birmingham 3-1 at home for a fourth successive win.
Southampton forward Sekou Mara's quickfire second-half double in the 3-0 FA Cup replay victory over Watford booked a fifth-round trip to Liverpool.
Republic of Ireland pair Gavin Bazunu and Will Smallbone both shone as Southampton moved up to second place in the Sky Bet Championship with a 3-1 victory at Swansea.
Republic of Ireland attacker Will Keane struck twice as Preston bounced back from two league defeats with a 2-0 win over Bristol City.
Leicester consolidated their position on top of the Championship with a 2-0 win at Cardiff, while their promotion rivals Ipswich were held to a 0-0 draw by struggling QPR on Friday. Kiernan Dewsbury-Hall and James Justin were on target for the Foxes in their 20th victory from 25 league games this term. Leicester are firm favourites for an immediate return to the Premier League after last season's relegation. They could also shatter Reading's record Championship points total of 106 set in the 2005-06 season.
Swansea City's reunion with former boss Russell Martin ended in abject humiliation as they were hammered by Southampton at St Mary's.