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Casper Ruud was one of three top seeds to exit the Mexican Open on Wednesday due to the effects of a stomach bug, while both Alexander Zverev and Ben Shelton suffered early defeats at the ATP 500 tournament in Acapulco.
Top-seeded Daniil Medvedev of Russia survived a day of upsets at the Dubai Tennis Championships, moving to the second round after a 6-4, 7-6 (4) win over Germany's Jan-Lennard Struff.
Top seed Taylor Fritz of the United States, the two-time defending champion at the Delray Beach (Fla.) Open, won't have a chance at a three-peat after falling to Spanish eighth seed Alejandro Davidovich Fokina 7-6 (4), 7-6 (5) on Friday in the quarterfinals.
Hometown favorite Thanasi Kokkinakis outlasted No. 8 seed Tomas Martin Etcheverry of Argentina in a 3-hour, 2-minute thriller on Wednesday at the Adelaide International in Australia.
Serbian Miomir Kecmanovic upset sixth-seeded Alexander Bublik of Kazakhstan 6-4, 6-2 in opening-round action at the Adelaide International in Australia on Tuesday
Tomas Machac of the Czech Republic rallied for a 6-7 (5), 6-4, 6-3 win over third seed Grigor Dimitrov of Bulgaria in two hours and 31 minutes to reach the Erste Bank Open quarterfinals on Thursday in Vienna, Austria.
Tommy Paul won his career-best 42nd singles match on tour this season, as the fourth seed defeated Laslo Djere 6-2, 7-6 (2) on Wednesday at the BNP Paribas Nordic Open in Stockholm.
The United States topped its group and ensured it will be seeded in the last eight of the Davis Cup Finals by beating Germany 2-1 on Saturday.